Dr. Linda Vahdat on Gelmbatumumab Vedotin as a Treatment in Triple Negative Breast Cancer

“With antibody drug conjugates, generally speaking is that you can deliver a much higher dose of drug to the tumor than you normally would be able to. The hope is that if you can deliver the drug to the tumor that you can kill more cancer cells.” – Linda Vahdat, M.D. 
Linda Vahdat, MD, professor of Medicine, director of the Breast Cancer Research Program, chief of the Solid Tumor Service, Weill Cornell Medical, discusses the antibody drug conjugate glembatumumab vedotin being used in the treatment of women with triple negative breast cancer who have a high expression of gpNMB. Vahdat says the purpose of the drug conjugate is to target gpNMB, also known as osteoactivan, which is important for cell migration and invasion.

Vahdat says the hope among oncologists for glembatumumab vedotin is that the treatment can deliver a much higher dose of drug to the tumor than you normally would be able to, and directly into the tumor cell.

Breast Center Team at American Society of Clinical Oncology Annual Meeting 2015 – Key Happenings!

We are excited to announce the Weill Cornell Medical College Breast Center’s contributions to the upcoming American Society of Clinical Oncology (ASCO) Annual Meeting next week!

Dr. Eleni Nackos (on behalf of Dr. Linda Vahdat) will be giving an oral presentation on the results from our phase 2 tetrathiomolybdate (TM) study. http://abstracts.asco.org/156/AbstView_156_151971.html

Dr. Tessa Cigler is chairing the Patient and Survivor Care session. Our abstract on cold caps was selected for a poster discussion session. http://abstracts.asco.org/156/AbstView_156_149240.html

Dr. Eleni Andreopoulou was selected by the International Development and Education Award (IDEA) group to mentor a physician from Morocco. Oncologists are selected by this group to host recipients for three-day visits following the ASCO meeting.

“The purpose of the IDEA program is to support the professional development of early-career oncologists in low- and middle-income countries around the world. The program pairs IDEA recipients with ASCO members in the United States or Canada who serve as their scientific mentors. Upon the mentees’ return to their home institution, it is expected that mentors and mentees remain in contact and pursue opportunities for consultation and collaboration.”

Dr. Anne Moore is chairing the Leadership Development Program presentation to the ASCO Board of Directors. The Leadership Development Program is a year-long program to learn leadership skills, gain exposure to the roles and mission of ASCO, and developing the future of cancer care. Dr. Moore is also joining the IDEA Working Group.

To view other abstracts from our studies:

PARP inhibitor ABT-888 http://abstracts.asco.org/156/AbstView_156_144933.html

Ovarian reserve and menses http://abstracts.asco.org/156/AbstView_156_147965.html

The METRIC study for metastatic triple negative breast cancer: http://abstracts.asco.org/156/AbstView_156_150265.html

IMMU study for metastatic triple negative breast cancer: http://abstracts.asco.org/156/AbstView_156_150673.html

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